About 15% of couples become pregnant following insemination with partner sperm,
while insemination with donor sperm has a slightly higher success rate. If no
pregnancy has been achieved after 3-4 attempts with insemination IVF is
recommended. Due to a low success rate the insemination method is generally
not recommended for women over the age of 40.
Insemination with partner sperm
Insemination with partner sperm is possible under the following conditions:
- Couples with mild male factor. In this case it is not alwas necessary to use hormone stimulation, as it is often times equally efficient to use spontaneous cycles. The spontaneous cycle reduces the twin pregnancy rate.
- Inexplicable childlessness. When no cause for childlessness can be found the successrate of insemination following hormone stimulation is higher than the rate when no stimulation is done.
- Mild to minimal endomentriosis.
The success rate is dependent on the number of motile sperm cells for
insemination. IUI is offered if insemination with minimum 2 million motile
sperm cells is possible. The rate of success is highest when 8 million/ml cells
are available for insemination.
Usually 3-4 inseminations are performed.
Insemination with donor sperm
In cases where the man's sperm cells are not suitable for treatment a donor can
be used, on the condition that the woman has open uterine tubes and ovulations.
Donor sperm can be used:
- If the sperm path is blocked.
- If the man has no sperm cells.
- If the sperm quality is low and the couple wants to avoid IVF/ICSI.
- If the man has infectious diseases such as HIV.
- If the man carries a genetic disease.
- In case of heavy rh-immunization from prior pregnancy.